Please find below a list of all GPEA projects to date, with PICOS, bottom lines and powerpoint attachments for those presented in 2016 – see previous post for more detail on 2015 GPEAs.
GPEAS in 2015
- Oral v Topical Antibiotics for Otitis Externa
- Olive Oil v Alternative topical treatments for Ear Wax
- Topical antibiotics+steroid v Topical antibiotics alone for Otitis Externa
- Chloramphenical v Placebo for Infective Conjunctivitis
GPEAS in 2016
Are triptans safe in pregnancy?
Abisola Seriki and Melissa Bonar
P = Pregnant women with typical migraine aged 18-40
I = Triptans
C = No medications or prophylaxis
O = Control of symptoms to be able to function
Clinical bottom line:
Consider use of a triptan after discussing need for treatment. Sumatriptan is the preferred triptan in pregnancy.
NSAID use in chicken pox
James Harper, Chris Phillips, Tom Hutchinson
P = Paediatric patients with varicella zoster
I = Use of NSAIDs
C = Use of placebo/avoidance of NSAIDs
O = Development of secondary streptococcal skin infections
Clinical bottom line:
- Underlying mechanism exists to suggest NSAIDs decrease neutrophil function
- Studies demonstrate an association between NSAID use in chickenpox and subsequent skin infections but not a causation.
- Case for paracetamol as first line in chickenpox
- Not enough to say avoid NSAIDS
Topical or oral treatment for vulvovagin acandidiasis
Helen Reay & Kate Shipton
P: Women with vulvovaginal candidiasis
I: Oral Fluconazole
C: Topical Clotrimazole (Pessary ± Cream)
O: Resolution of symptoms
Clinical bottom line:
- Clinical outcomes not significantly different
- Therefore cost and patient choice will influence prescribing practice
Should we prescribe antibiotics for sore throat?
Gerald Clancy, Alice Young and Selina Soukup
P = Sore throat in adults and children
I = antibiotic therapy
C = no antibiotics/supportive therapy only
O =
- Primary – Duration of symptoms
- Secondary – Suppurative complication (otitis media within 14 days, acute sinusitus within 14 days, quinsy within 2 months)
Clinical bottom line:
Antibiotics shorten duration of symptoms by about 16 hours overall.